一、个人简介

1．基本情况：

赵国琰，女，中共党员，教授，博士生导师；山东省优秀青年基金获得者，365英国上市东岳学者青年人才；现任微生物与动物疾病教师党支部书记、微生物学教研室主任、微生物学硕士学位点负责人；兼任山东省微生物学会常务理事、山东省微生物学会专业委员会委员及青年委员会委员、山东省菌物学学会常务理事、山东农学会农业微生物专业委员会副主任、山东省留学人员协会副秘书长、英国利物浦大学荣誉研究员。

以第一作者或通讯作者身份在Nature Communications、Science Advances、The Plant Journal、Journal of Biological Chemistry、Molecular Microbiology等国际知名刊物发表SCI学术论文多篇，参编《中国学科发展战略—化学生物学》；主持国家863计划海洋领域子课题、国家自然科学基金项目、山东省优秀青年基金项目、山东省青创人才选育计划项目（200万）、山东省自然科学基金面上项目、江苏省自然科学基金项目、全国博士后国际交流计划派出项目等；获多项授权发明专利。

指导学生获全国大学生生命科学竞赛国家级一等奖2项、山东省优秀硕士学位论文、研究生国家奖学金、国家级大学生创新创业训练计划项目多项。参与国家级一流本科课程（微生物学）及省级课程思政示范课程（微生物学）建设；主持365英国上市专创融合课程（微生物学）。课题组学术气氛浓厚、关注个人发展、鼓励创新、自由探索、松弛有度、人际关系和谐。

2．教育经历：

2006/09-2011/07，山东大学，微生物技术国家重点实验室，博士

2002/09-2006/07, 山东大学，英国365公司基地班，学士

3．工作经历：

2014/09至今，365英国上市

（期间2017/10-2019/09，英国约克大学，博士后）

2011/07-2014/08，南京大学

4. 联系方式：

邮箱：zhaoguoyan@sdnu.edu.cn；地址：博物楼433室

二、研究方向

1．蓝细菌细胞图谱构建及光合作用机制研究

开展细长聚球藻PCC 7942高通量亚细胞定位与蛋白互作技术（CyanoTag）的开发应用；探究液–液相分离现象及其分子机制；解析新型光系统组装辅助因子的功能；研究蓝细菌细胞分裂与形态发生过程中的基因调控机制。

2．耐盐碱微生物与作物互作机制研究

开展盐碱地植物根际及内生细菌和藻类的分离、鉴定及其促生功能研究；解析湿地植物内生细菌介导植物表面微纳米锰氧化物生物合成的机制；阐明内生细菌强化植物修复环境的途径与机制；挖掘重要功能基因与代谢物；解析根际及内生细菌与植物互作介导的抗逆机制。

三、承担项目

1.国家自然科学基金：“高活性耐盐碱微生物改良盐碱地的作用机制”（U24A20613）联合基金项目子课题，2025.01-2028.12

2.山东省自然科学基金面上项目：“黄河三角洲盐生植物内生锰氧化细菌 4-3-1 降低菠菜镉吸收的互作机制和生态效应”（ZR2024MC202）2025.01-2027.12

3.山东省高等学校青年创新团队人才引育计划：“微生物学研究创新团队” （426-121109）2022.01-2024.12

4.山东省自然科学基金面上项目：“柽柳内生细菌栖盐田菌的锰氧化性质及其功能蛋白研究”（ZR2020MC002）2021.01-2023.12

5.国家重点实验室开放基金项目：“新型锰氧化酶StKatG介导微生物锰氧化的分子机制探究”（GZKF202320） 2024.01-2025.12

6.全国博士后派出项目：“湿地植物内生细菌介导宿主表面锰氧化膜合成的动态过程和分子机制研究”（20170058）2017.10-2019.09

7.山东省自然科学基金优秀青年基金：“黄河三角洲三种盐生植物内生细菌的分离鉴定及其促生耐盐机制研究”（2015ZRB01ALJ）2015.05-2016.12

8.国家自然科学基金：“黄河三角洲盐生植物内生细菌在锰氧化物生物合成中的作用及分子机制研究”（31640002）2017.01-2017.12

9.国家自然科学基金：“新型真菌漆酶LacTL对萘酚化合物的对映选择”（21302091）2014.01-2016.12

10.国家863计划海洋技术领域主题项目子课题：“海洋微生物先导化合物的生物合成调控与产率优化”（2013AA092901）2013.01-2015.12

11.江苏省自然科学基金：“真菌漆酶LACS的不对称C-C偶合功能研究”（BK2012308）2012.07-2015.06

12.全国博士后派出项目：“湿地植物内生细菌介导宿主表面锰氧化膜合成的动态过程和分子机制研究”（20170058）2017.10-2019.09

13.中国博士后科学基金面上资助：“湿地植物内生细菌在锰氧化物形成过程中的作用研究”（2016M600551）2016.10-2019.10

14.生物反应器工程国家重点实验室开放课题：“新型免疫抑制剂Dalesconol的代谢调控与发酵优化” 2013.06-2015.05

15.中央高校基本科研业务费：“Daldinia eschscholziiIFB-TL01所产漆酶lacTLs的对映选择性催化性质及机制研究” 2013.01-2013.12

16.中央高校基本科研业务费苗圃项目：“新型真菌漆酶LacTL对萘酚化合物的对映选择性催化机制” 2014.01-2014.12

四、科研成果

1．发表文章（#第一作者，*通讯作者）：

① Shoujin Fan^#, Wenzhe Li^#, Zhuo Chen^#, Zixu Wang, Xiang Cheng, Susu Zhang, Meixue Dai, Jinyu Yang, Leilei Chen*, Guoyan Zhao*. Pyridoxine dehydrogenase SePdx regulates photosynthesis via an association with the phycobilisome in a cyanobacterium. The Plant Journal, 2025, 121, e70055.

② Abigail J. Perrin^#, Matthew Dowson, Katharine Davis, Onyou Nam, Adam A. Dowle, Grant Calder, Victoria J. Springthorpe, Guoyan Zhao^*, Luke C. M. Mackinder^*. CyanoTag: Discovery of protein function facilitated by high-throughput endogenous tagging in a photosynthetic prokaryote. Science Advances, 2025, 11, eadp6599.

③ Shuai Liu#, Lin-Li Yao#, Xin-Ru Wang, Guo-Yan Zhao, Fei Li, Bing-Jian Yao*，Yu-Bin Dong. BODIPY and N -Halamine-Decorated Covalent Organic Framework with Synergistic Antibacterial Capabilities for Sunlight-Powered Water Sterilization. Journal of Hazardous Materials, 2025, 13 (6), 4530–4537.

④ Mengyao Ding^#, Wenjing Wang^#, Zhenkun Lu, Yuhui Sun, Xinzhen Qiao, Meixue Dai, Guoyan Zhao^*. Catalase-peroxidase StKatG2 from Salinicola tamaricis: a versatile Mn(II)oxidase that decolorizes malachite green. Frontiers in Microbiology, 2024,15:1478305

⑤ Yingxin Huo#, Fanghong Zou^#, Zihui You, Guoyan Zhao, Meixue Dai, Susu Zhang^*. Cold-active β-galactosidase from Weissella confusa SW1 for the preparation of low-lactose milk. International Journal of Food Microbiology, 2024, 224, 281-291

⑥ Fanghong Zou^#, Yingxin Huo ^#, Wenyue Gao, Meixue Dai, Guoyan Zhao^*, Susu Zhang^*. Physicochemical, microbiological and sensory characterization of yogurt fermented by Weissella confusa SW1 and traditional starters. LWT - Food Science and Technology, 2024, 201,116229

⑦ Runlei Chang^#, Yichen Wang, Yanyu Liu, Yiran Wang, Shiguo Li, Guoyan Zhao, SusuZhang , Meixue Dai, Xiaoxiao Zheng, Tanay Bose^*, Hongli Si^*. Nine new species of black lichenicolous fungi from the genus Cladophialophora (Chaetothyriales) from two different climatic zones of China. Frontiers in Microbiology, 2023,14:1191818

⑧ Guoyan Zhao^#*,Wenjing Wang^#, Linlin Zheng, Leilei Chen, Guowen Duan, Runlei Chang, Zhuo Chen, Susu Zhang, Meixue Dai, Guiwen Yang^*. Catalase-peroxidase StKatG is a bacterial manganese oxidase from endophytic Salinicola tamaricis. International Journal of Biological Macromolecules. 2023, doi: 10.1016/j.ijbiomac.2022.10.123

⑨ Wenxiu Wu^#, Fei Li^#, Bingjian Yao^*, Luogang Ding, Jinglan Kan, Fei Liu, Guoyan Zhao , Song Wang, Yubin Dong^*. Synthesis of covalent organic frameworks via Kabachnik-Fields reaction for water treatment. Journal of Hazardous Materials, 2022, 433, 128831

⑩ Zixu Gao^#, Wenchang Zhang^#, Runlei Chang, Susu Zhang, Guiwen Yang^*, Guoyan Zhao^*. Liquid-liquid phase separation: unravelling the enigma of biomolecular condensates in microbial cells. Frontiers in Microbiology, 2021, 12:75188

11 Yuankai Sun^#, Yonggang Zhang^#, Wenzhe Li, Wenchang Zhang, Zhenlu Xu, Meixue Dai, Guoyan Zhao^*. Combination of the endophytic manganese-oxidizing bacterium Pantoea eucrina SS01 and biogenic Mn oxides: An efficient and sustainable complex in degradation and detoxification of malachite green. Chemosphere, 2021,280,130785

12 Luo-Gang Ding^#, Song Wang, Bing-Jian Yao^*, Fei Li, Yan-An Li, Guo-Yan Zhao, Yu-Bin Dong^*. Synergistic Antibacterial and Anti-Inflammatory Effects of a Drug-Loaded Self-Standing Porphyrin-COF Membrane for Efficient Skin Wound Healing. Advanced Healthcare Materials, 2021, 10, 2001821

13 Runlei Chang^#, Xiuyu Zhang, Hongli Si, Guoyan Zhao, Xiaowen Yuan, Tengteng Liu,Tanay Bose, Meixue Dai^*. Ophiostomatoid species associated with pine trees (Pinus spp.) infested by Cryphaluspiceae from eastern China, including five new species. MycoKeys, 2021，83:181–208

14 Jun Chen#, Na Li#, Sheng Han, Yuankai Sun, Lili Wang, Zhili Qu, Meixue Dai, Guoyan Zhao* Characterization and bioremediation potential of nickel-resistant endophytic bacteria isolated from the wetland plant Tamarix chinensis. FEMS Microbiol Lett. FEMS Microbiology Letters 2020 Jun 1;367(12):fnaa098.

15 Han S^#, Han WB^#, Chen J, Sun YK, Dai MX, Zhao GY*: Bioremediation of malachite green by cyanobacterium Synechococcus elongatus PCC 7942 engineered with a triphenylmethane reductase gene. Applied Microbiology and Biotechnology 2020. 104:3193–3204.

16 Zhao GY^#*, Cheng JH^#, Sun NN, Ma CL, Dai MX: Two endophytic bacterial strains modulate Mn oxidation and accumulation in the wetland plant Suaeda salsa pall. Plant and Soil 2019, 438(1):223-237.

17 Shang NJ^#, Ding MJ^#, Dai MX, Si HL, Li SG, Zhao GY*: Biodegradation of malachite green by an endophytic bacterium Klebsiella aerogenes S27 involving a novel oxidoreductase. Applied Microbiology and Biotechnology 2019, 103(5):2141-2153.

18 Zhao GY^#, Shao F^#, Zhang M, Zhang XJ, Wang JY, Fan SJ*, Dai MX*: Luteimonas rhizosphaerae sp. nov., isolated from the rhizosphere of Triticum aestivum L. International Journal of Systematic and Evolutionary Microbiology 2018, 68(4):1197-1203.

19 Shang NJ, Zhu QQ, Dai MX, Zhao GY*: Complete genome sequence of the heavy-metal-tolerant endophytic type strain of Salinicola tamaricis. Genome Announcements 2018, 6(16):e00358-00318.

20 Zhao GY^#, Zhao LY^#, Xia ZJ, Zhu JL, Liu D, Liu CY, Chen XL, Zhang YZ, Zhang XY*, Dai MX*: Salinicola tamaricis sp. nov., a heavy-metal-tolerant, endophytic bacterium isolated from the halophyte Tamarix chinensis Lour. International Journal of Systematic and Evolutionary Microbiology 2017, 67(6):1813-1819.

21 Casella S, Huang F, Mason D, Zhao GY, Johnson GN, Mullineaux CW, Liu LN*: Dissecting the native architecture and dynamics of cyanobacterial photosynthetic machinery. Molecular Plant 2017, 10(11):1434-1448.

22 Xia ZJ, Wu HZ, Cui CX, Chen Q, Zhao GY, Wang HX, Dai MX*: Larsenimonas suaedae sp. nov., a moderately halophilic, endophytic bacterium isolated from the euhalophyte Suaeda salsa. International Journal of Systematic and Evolutionary Microbiology 2016, 66(8):2952-2958.

23 Zhao GY^#, Fan JY^#, Hua CP, Yan W, Chen C, Lu YH, Jiao RH*, Tan RX*: Resveratrol improves fungal ribosylation capacity through a unique mechanism. RSC Advances 2015, 5(8):5657-5663.

24 Tian Y^#, Zhao GY^#, Fang W^#, Xu Q, Tan RX*: Δ10(E)-Sphingolipid Desaturase involved in Fusaruside mycosynthesis and stress adaptation in Fusarium graminearum. Scientific Reports 2015, 5:10486.

25 Song YN, Jiao RH, Zhang WJ, Zhao GY, Dou H, Jiang R, Zhang AH, Hou YY, Bi SF, Ge HM*, Tan RX*: New ansamycin derivatives generated by simultaneous mutasynthesis. Organic Letters 2015, 17(3):556-559.

26 Ran LY^#, Su HN^#, Zhao GY^#, Gao X, Zhou MY, Wang P, Zhao HL, Xie BB, Zhang XY, Chen XL, Zhou BC, Zhang YZ*: Structural and mechanistic insights into collagen degradation by a bacterial collagenolytic serine protease in the subtilisin family. Molecular Microbiology 2013, 90(5):997-1010.

27 Qiao HS, Chen XQ, Xu LF, Wang JJ, Zhao GY, Hou YY, Ge HM, Tan RX*, Li EG*: Antitumor effects of naturally occurring oligomeric resveratrol derivatives. FASEB Journal 2013, 27(11):4561-4571.

28 Fang W^#, Ji S^#, Jiang N^#, Wang W^#, Zhao GY^#, Zhang S, Ge HM, Xu Q, Zhang AH, Zhang YL, Song YC, Zhang J, Tan RX*: Naphthol radical couplings determine structural features and enantiomeric excess of dalesconols in Daldinia eschscholzii. Nature Communications 2012, 3:1039. （并列第一作者，按姓氏排名）

29 Zhao GY^#, Zhou MY, Zhao HL, Chen XL*, Xie BB, Zhang XY, He HL, Zhou BC, Zhang YZ: Tenderization effect of cold-adapted collagenolytic protease MCP-01 on beef meat at low temperature and its mechanism. Food Chemistry 2012, 134(4):1738-1744.

30 Wang YK^#, Zhao GY^#, Li Y, Chen XL, Xie BB, Su HN, Lv YH, He HL, Liu H, Hu J, Zhou BC, Zhang YZ*: Mechanistic insight into the function of the C-terminal PKD domain of the collagenolytic serine protease deseasin MCP-01 from deep sea Pseudoalteromonas sp. SM9913: binding of the PKD domain to collagen results in collagen swelling but does not unwind the collagen triple helix. The Journal of Biological Chemistry 2010, 285(19):14285-14291.

31 Zhao GY^#, Chen XL^#, Zhao HL, Xie BB, Zhou BC, Zhang YZ*: Hydrolysis of insoluble collagen by deseasin MCP-01 from deep-sea Pseudoalteromonas sp. SM9913: collagenolytic characters, collagen-binding ability of C-terminal polycystic kidney disease domain, and implication for its novel role in deep-sea sedimentary particulate organic nitrogen degradation. The Journal of Biological Chemistry 2008, 283(52):36100-36107.

32 参编《中国学科发展战略-化学生物学》（科学出版社），ISBN9787030433992，出版时间2015-4-1。

2．授权专利：

① 赵国琰，丁梦瑶，李文喆，鲁振堃 微小杆菌4-3-1及其应用，专利号：ZL 2024 1 0850423.6， 授权日: 2024.08.30

② 赵国琰，孙元凯，王文静 一株泛菌及菌锰混合物及在降解孔雀石绿中的应用，专利号：ZL 2021 10484181.X，授权日:2023年03月21日

③ 赵国琰，尚念杰，一株在高盐环境下降解孔雀石绿的产气肠杆菌，专利号：ZL 2017 1 1180830.7，授权公告号：CN 107858303 B，授权日：2020. 02.07。

④ 赵国琰，尚念杰，丁梦娇，一种消煮专用圆底烧瓶放置架，授权号：CN 207856954 U. 授权日 : 2018.09.14。

五、荣誉奖励

2023年 365英国上市“三八红旗手”

2010年 教育部首届博士研究生学术新人奖

2020年 山东省优秀硕士学位论文指导教师

2025年 全国大学生生命科学竞赛国家级一等奖指导教师

2021年 365英国上市敬业担当党员先锋岗

2021年 365英国上市首届教师教学创新大赛二等奖